🧠 When an Algorithm Flags Your Cancer First

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AIHealthTech Insider: Issue #79

December 15, 2025

This issue explores practical advances in clinical AI and digital health, including nutraceutical strategies for glioblastoma, AI-guided vaccine targets, FDA-cleared digital therapeutics for ADHD, noninvasive glucose monitoring, early dementia detection, and health AI deployment in Africa. It highlights the transition of AI and data-driven tools from research to care, impacting clinicians, health systems, and policymakers.

^{Summaries are for education, not medical advice. Always verify locally before clinical use}.

🧪 Simple Supplement Combo Shows Promise in Aggressive Brain Cancer

A small clinical study found that a low-cost nutraceutical combination of resveratrol and copper significantly reduced tumor aggressiveness in glioblastoma patients. The approach works by neutralizing inflammatory DNA fragments released from dying cancer cells, leading to lower cancer markers, immune checkpoints, and stem-cell signals all without reported side effects.

Why it matters

• Challenges the “kill the tumor” paradigm with a tumor-healing strategy

• Reduces multiple cancer hallmarks, immune checkpoints, and stem-cell markers

• Offers a non-toxic, inexpensive adjunct to existing brain cancer treatments

Limitation: small-sample, early-stage

👉 Study → Attenuation of malignant phenotype of glioblastoma following a short course of the pro-oxidant combination of Resveratrol and Copper | BJC Reports

🧬 AI Uncovers a Hidden Monkeypox Weak Spot That Could Redefine Vaccines

Researchers used AI to identify a previously overlooked monkeypox surface protein (OPG153) that triggers strong neutralizing antibodies. When tested as a vaccine antigen in mice, the protein produced a potent immune response, pointing to simpler, more targeted mpox and smallpox vaccines than current whole-virus approaches.

Why it matters

• Reveals a single-protein vaccine target that’s easier and cheaper to manufacture

• Uses AI (AlphaFold 3) to dramatically accelerate antigen discovery

• Enables next-generation mpox and smallpox vaccines without live viruses

• Demonstrates how AI-driven “reverse vaccinology” can reshape vaccine design

So What: For clinicians, potential impact on future outbreak responses

👉 Study → Antigen-agnostic identification of poxvirus broadly neutralizing antibodies targeting OPG153 | Science Translational Medicine

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😄Do You Know? LumosityRx Becomes FDA-Cleared Digital Treatment for Adult ADHD

Lumosity has launched LumosityRx, an FDA-cleared prescription digital therapeutic for adults with ADHD, translating nearly two decades of cognitive training science into a clinically validated treatment option for attention improvement.

Why it matters

• Expands ADHD treatment beyond medication with an evidence-based digital option

• Backed by a large randomized controlled trial (560 adults across 13 clinical sites)

• Demonstrated statistically significant gains in sustained and selective attention (TOVA®)

• Showed clinician-rated improvement and quality-of-life benefits with minimal side effects

LumosityRx delivers a personalized, adaptive training program (~15 minutes/day) using 13 targeted cognitive exercises. The FDA clearance marks a major milestone for prescription digital therapeutics, signaling how consumer cognitive science platforms can evolve into regulated clinical treatments.

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👉 Product → LumosityRx - FDA-Cleared Prescription Therapeutic App for ADHD

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🩺Product Spotlight: MIT’s Raman-Based Noninvasive Glucose Monitor

MIT researchers have unveiled a shoebox-sized, light-based glucose monitoring device that measures blood glucose directly through the skin in under a minute—without finger pricks or implanted sensors. Using band-pass Raman spectroscopy (BRS), the system isolates glucose’s molecular signature with just a few optical bands, avoiding complex AI-heavy models while delivering accuracy comparable to today’s invasive CGMs.

Why it matters

• Enables truly noninvasive, point-of-care glucose monitoring

• Reduces reliance on finger pricks and under-the-skin sensors

• Compact, low-cost design avoids full-spectrum optics and heavy AI

• Early results closely match commercial CGMs in pilot testing

👉 Study →Band-Pass Raman Spectroscopy Unlocks Compact Point-of-Care Noninvasive Continuous Glucose Monitoring | Analytical Chemistry

✨ Surprise: AI Tool Detects Dementia Earlier in Primary Care

A large clinical trial demonstrates that a fully digital AI approach, using patient-reported cognitive surveys and an NLP-based EHR algorithm, can boost early detection of Alzheimer’s and related dementias in primary care by ~31% within 12 months without additional costs or resources.

Why it matters

• Enables scalable, zero-burden dementia screening in primary care

• Leverages EHR data + patient input to catch cases often missed

• Improves equity by identifying at-risk patients earlier across populations

👉 Study → Digital Detection of Dementia in Primary Care: A Randomized Clinical Trial | JAMA Network Open

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🌍 Google-Backed AI Ideathon Advances Healthcare Across Africa

Google Research supported an Africa-wide Data Science for Health Ideathon, enabling researchers to apply open health AI models to real-world challenges like cervical cancer screening and maternal health. Using MedGemma, MedSigLIP, and TxGemma, teams created scalable solutions validated through mentorship, compute support, and expert review.

Why it matters

• Translates open health AI models into real clinical workflows

• Enables low-connectivity, multilingual healthcare solutions

• Empowers local teams to solve local health priorities

• Demonstrates scalable AI-for-health collaboration beyond labs

👉 Article → Spotlight on innovation: Google-sponsored Data Science for Health Ideathon across Africa

💡 Poll: Health Data & AI Development

Hit reply with which study you’d pilot first in your hospital.

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